Work will begin on Monday to carry out surface treatment works on A148 London Road/St James Road, Lynn between the South Gates and Railway Road.
The works will be carried out overnight and will take three nights to complete.
During the works a one-way system will be used to control traffic.
Inbound traffic will use London Road as normal, however all outbound traffic will be diverted via A148 Railway Road, Littleport Street, Gaywood Road and B1144 Tennyson Avenue between 7pm and 7am.
All traffic exiting via any side road on to London Road/St James Road will also be required to follow the temporary diversion.
Access to businesses and properties will be maintained but it is inevitable that there will be some disruption. Norfolk County Council apologised for any inconvenience this may cause.